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Mortality associated with attention-deficit hyperactivity disorder (ADHD) drug treatment: a retrospective cohort study of children, adolescents and young adults using the general practice research database

Authors:

Suzanne McCarthy, Noel Cranswick, Laura Potts, Eric Taylor, Ian C K Wong

Key summary:

 

The study found no increased risk of sudden death associated with attention-deficit hyperactivity disorder (ADHD) medications [methylphenidate (Ritalin®), dexamfetamine (Dexedrine®), and atomoxetine (Strattera®)]. An increased risk of suicide was seen in the patients with medication prescription in the study comparing with the general population, but such risk may be contributed by other factors such as common psychiatric co-morbidities e.g. bipolar disorder, depression and anti-social behaviour. Special attention and close monitoring should be given to patients with severe co-morbid conditions, increased risks of cardiovascular events and suicide.

Reference:

McCarthy S, Cranswick N, Potts L, Taylor E, Wong IC. Mortality associated with attention-deficit hyperactivity disorder (ADHD) drug treatment: a retrospective cohort study of children, adolescents and young adults using the general practice research database. Drug Saf 2009; 32(11): 1089-96.

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